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  • 向少华

    研究教授(硕士生导师）
    • 邮箱：xiangsh@sustech.edu.cn
    办公室：南方科技大学慧园6栋301室
    个人主页：
    http://faculty.sustech.edu.cn/xiangsh/


    • 基本介绍
    • 研究方向
    • 学术成果
    • 其它信息
    2006年本科毕业于厦门大学化学系；保送厦门大学化学系读研，师从黄培强教授，2009年获得硕士学位；2015年博士毕业于新加坡南洋理工大学化学与生物化学系，师从刘学伟教授。随后回国入职深圳华大基因研究院。2017年9月加入南方科技大学，聚焦轴手性化学这一前沿领域，围绕轴手性的催化不对称构建与应用开展系统性研究。至今已在国内外期刊上发表高水平研究论文70余篇，其中以通讯作者和第一作者（含共同）身份发表论文30余篇，包括1篇Nat. Chem.、1篇Nat. Catal.、2篇Chem、2篇J. Am. Chem. Soc.、6篇Angew. Chem. Int. Ed.及1篇Nat. Commun.。论文中引用近4000次，H指数为33。参与编写WILEY出版社的《Axially Chiral Compounds: Asymmetric Synthesis and Applications》与《Catalytic Asymmetric Synthesis》中多个章节，主持国家、省、市级项目5项，包含国家自然科学基金面上项目，国家自然科学青年基金，广东省自然科学基金杰出青年基金。

    不对称有机催化，轴手性化学，糖基化

    1. Hao-Wen Zhao, Fei Jiang, Sihan Chen, Jingliang Hu, Shao-Hua Xiang*, Wei-Yi Ding, Wei Lu*, Bin Tan*. Organocatalytic asymmetric construction and application of axially chiral spiro-bisindoles. Chem. Int. Ed. 2025, 64, e202422951.
    2. Shi-Jiang He, Boming Shen, Lian-Zheng Zuo, Shao-Hua Xiang*, Huan-Huan Liu, Peiyuan Yu*, Bin Tan*. Enantioselective construction of anthracenylidene-based axial chirality by asymmetric Heck reaction. Am. Chem. Soc. 2024, 146, 19137.
    3. Shao-Hua Xiang, Wei-Yi Ding*, Yong-Bin Wang, Bin Tan*. Catalytic atroposelective synthesis. Catal. 2024, 7, 483.
    4. Peng-Ying Jiang, San Wu, Guan-Jun Wang, Shao-Hua Xiang*, Bin Tan*. Synthesis of axially chiral QUINAP derivatives by ketone-catalyzed enantioselective oxidation. Chem. Int. Ed. 2023, 62, e202309272.
    5. Jun Wei, Jian Zhang, Jun Kee Cheng, Shao-Hua Xiang*, Bin Tan*. Modular enantioselective access to β-amino amides by Brønsted acid-catalyzed multicomponent reactions. Chem. 2023, 15, 647.
    6. Xu-Jie Wang, Huan-Huan Liu, Jun Kee Cheng, Shao-Hua Xiang*, Bin Tan*. Catalytic enantioselective synthesis of chiral sulfonium ylides with S-stereogenic center. Chem 2023, 9, 1495.
    7. Shi-Jiang He, Shuai Zhu, Sheng-Qi Qiu, Wei-Yi Ding*, Jun Kee Cheng, Shao-Hua Xiang*, Bin Tan*. Phosphoric acid-catalyzed enantioselective synthesis of axially chiral anthrone-based compounds. Chem. Int. Ed. 2023, 62, e202213914.
    8. Wei-Yi Ding, Huan-Huan Liu, Jun Kee Cheng, Hui Yao*, Shao-Hua Xiang*, Bin Tan. Palladium catalyzed decarboxylative β-C-glycosylation of glycals with oxazol-5-(4H)-ones as acceptors. Chem. Front. 2022, 9, 6149.
    9. Wei-Yi Ding, Hao-Wen Zhao, Jun Kee Cheng, Zhiqiang Lu*, Shao-Hua Xiang*, Bin Tan. β-C-glycosylation with 2-oxindole acceptors via palladium-catalyzed decarboxylative reactions. Lett. 2022, 24, 7031.
    10. Shuai Zhu, Jian-Hui Mao, Jun Kee Cheng, Shao-Hua Xiang*, Bin Tan*. Discovery and organocatalytic enantioselective construction of axially chiral cyclohexadienylidene skeletons. Chem 2022, 8, 2529.
    11. Wang Xia, Zi-An Zhou, Jie Lv, Shao-Hua Xiang*, Yong-Bin Wang, Bin Tan*. Facile synthesis of N-aryl phenothiazines and phenoxazines via Brønsted acid catalyzed C–H amination of arenes. Commun. 2022, 58, 1613.
    12. Junxian Yang, Ji-Wei Zhang, Wen Bao, Sheng-Qi Qiu, Shaoyu Li, Shao-Hua Xiang*, Jun Song, Junmin Zhang*, Bin Tan*. Chiral phosphoric acid-catalyzed remote control of axial chirality at boron–carbon bond. Am. Chem. Soc. 2021, 143, 12924.
    13. Song Chen, Ya-Nan Li, Shao-Hua Xiang*, Shaoyu Li*, Bin Tan*. Electrochemical phenothiazination of naphthylamines and its application in photocatalysis. Comm. 2021, 57, 8512.
    14. Shao-Hua Xiang, Bin Tan*. Advances in asymmetric organocatalysis over the last 10 years. Commun. 2020, 11, 3786.
    15. Ye-Hui Chen, Heng-Hui Li, Xiao Zhang, Shao-Hua Xiang*, Shaoyu Li, Bin Tan*. Organocatalytic enantioselective synthesis of atropisomeric aryl-p-quinones: Platform molecules for diversity-oriented synthesis of biaryldiols. Chem. Int. Ed. 2020, 59, 11374.
    16. Yong-Bin Wang, Quan-Hao Wu, Zhi-Peng Zhou, Shao-Hua Xiang*, Yuan Cui, Peiyuan Yu, Bin Tan*. Asymmetric construction of axially chiral 2-arylpyrroles by chirality transfer of atropisomeric alkenes. Chem. Int. Ed. 2019, 58, 13443.
    17. Lin-Lin Zhang, Ji-Wei Zhang, Shao-Hua Xiang*, Zhen Guo*, Bin Tan*. Remote control of axial chirality: Synthesis of spirooxindole–urazoles via desymmetrization of ATAD. Lett. 2018, 20, 6022.
    18. Shao-Hua Xiang, Kim Le Mai Hoang, Jing-Xi He, Yu-Jia Tan, Xue-Wei Liu*. Reversing the Stereoselectivity of a Palladium-catalyzed O-glycosylation through an inner-sphere or outer-sphere pathway. Chem. Int. Ed. 2015, 54, 604.

向少华研究教授(硕士生导师）

邮箱：xiangsh@sustech.edu.cn
办公室：南方科技大学慧园6栋301室
个人主页：
http://faculty.sustech.edu.cn/xiangsh/


  • 基本介绍
  • 研究方向
  • 代表性论文
  • 其它信息
2006年本科毕业于厦门大学化学系；保送厦门大学化学系读研，师从黄培强教授，2009年获得硕士学位；2015年博士毕业于新加坡南洋理工大学化学与生物化学系，师从刘学伟教授。随后回国入职深圳华大基因研究院。2017年9月加入南方科技大学，聚焦轴手性化学这一前沿领域，围绕轴手性的催化不对称构建与应用开展系统性研究。至今已在国内外期刊上发表高水平研究论文70余篇，其中以通讯作者和第一作者（含共同）身份发表论文30余篇，包括1篇Nat. Chem.、1篇Nat. Catal.、2篇Chem、2篇J. Am. Chem. Soc.、6篇Angew. Chem. Int. Ed.及1篇Nat. Commun.。论文中引用近4000次，H指数为33。参与编写WILEY出版社的《Axially Chiral Compounds: Asymmetric Synthesis and Applications》与《Catalytic Asymmetric Synthesis》中多个章节，主持国家、省、市级项目5项，包含国家自然科学基金面上项目，国家自然科学青年基金，广东省自然科学基金杰出青年基金。

不对称有机催化，轴手性化学，糖基化

  1. Hao-Wen Zhao, Fei Jiang, Sihan Chen, Jingliang Hu, Shao-Hua Xiang*, Wei-Yi Ding, Wei Lu*, Bin Tan*. Organocatalytic asymmetric construction and application of axially chiral spiro-bisindoles. Chem. Int. Ed. 2025, 64, e202422951.
  2. Shi-Jiang He, Boming Shen, Lian-Zheng Zuo, Shao-Hua Xiang*, Huan-Huan Liu, Peiyuan Yu*, Bin Tan*. Enantioselective construction of anthracenylidene-based axial chirality by asymmetric Heck reaction. Am. Chem. Soc. 2024, 146, 19137.
  3. Shao-Hua Xiang, Wei-Yi Ding*, Yong-Bin Wang, Bin Tan*. Catalytic atroposelective synthesis. Catal. 2024, 7, 483.
  4. Peng-Ying Jiang, San Wu, Guan-Jun Wang, Shao-Hua Xiang*, Bin Tan*. Synthesis of axially chiral QUINAP derivatives by ketone-catalyzed enantioselective oxidation. Chem. Int. Ed. 2023, 62, e202309272.
  5. Jun Wei, Jian Zhang, Jun Kee Cheng, Shao-Hua Xiang*, Bin Tan*. Modular enantioselective access to β-amino amides by Brønsted acid-catalyzed multicomponent reactions. Chem. 2023, 15, 647.
  6. Xu-Jie Wang, Huan-Huan Liu, Jun Kee Cheng, Shao-Hua Xiang*, Bin Tan*. Catalytic enantioselective synthesis of chiral sulfonium ylides with S-stereogenic center. Chem 2023, 9, 1495.
  7. Shi-Jiang He, Shuai Zhu, Sheng-Qi Qiu, Wei-Yi Ding*, Jun Kee Cheng, Shao-Hua Xiang*, Bin Tan*. Phosphoric acid-catalyzed enantioselective synthesis of axially chiral anthrone-based compounds. Chem. Int. Ed. 2023, 62, e202213914.
  8. Wei-Yi Ding, Huan-Huan Liu, Jun Kee Cheng, Hui Yao*, Shao-Hua Xiang*, Bin Tan. Palladium catalyzed decarboxylative β-C-glycosylation of glycals with oxazol-5-(4H)-ones as acceptors. Chem. Front. 2022, 9, 6149.
  9. Wei-Yi Ding, Hao-Wen Zhao, Jun Kee Cheng, Zhiqiang Lu*, Shao-Hua Xiang*, Bin Tan. β-C-glycosylation with 2-oxindole acceptors via palladium-catalyzed decarboxylative reactions. Lett. 2022, 24, 7031.
  10. Shuai Zhu, Jian-Hui Mao, Jun Kee Cheng, Shao-Hua Xiang*, Bin Tan*. Discovery and organocatalytic enantioselective construction of axially chiral cyclohexadienylidene skeletons. Chem 2022, 8, 2529.
  11. Wang Xia, Zi-An Zhou, Jie Lv, Shao-Hua Xiang*, Yong-Bin Wang, Bin Tan*. Facile synthesis of N-aryl phenothiazines and phenoxazines via Brønsted acid catalyzed C–H amination of arenes. Commun. 2022, 58, 1613.
  12. Junxian Yang, Ji-Wei Zhang, Wen Bao, Sheng-Qi Qiu, Shaoyu Li, Shao-Hua Xiang*, Jun Song, Junmin Zhang*, Bin Tan*. Chiral phosphoric acid-catalyzed remote control of axial chirality at boron–carbon bond. Am. Chem. Soc. 2021, 143, 12924.
  13. Song Chen, Ya-Nan Li, Shao-Hua Xiang*, Shaoyu Li*, Bin Tan*. Electrochemical phenothiazination of naphthylamines and its application in photocatalysis. Comm. 2021, 57, 8512.
  14. Shao-Hua Xiang, Bin Tan*. Advances in asymmetric organocatalysis over the last 10 years. Commun. 2020, 11, 3786.
  15. Ye-Hui Chen, Heng-Hui Li, Xiao Zhang, Shao-Hua Xiang*, Shaoyu Li, Bin Tan*. Organocatalytic enantioselective synthesis of atropisomeric aryl-p-quinones: Platform molecules for diversity-oriented synthesis of biaryldiols. Chem. Int. Ed. 2020, 59, 11374.
  16. Yong-Bin Wang, Quan-Hao Wu, Zhi-Peng Zhou, Shao-Hua Xiang*, Yuan Cui, Peiyuan Yu, Bin Tan*. Asymmetric construction of axially chiral 2-arylpyrroles by chirality transfer of atropisomeric alkenes. Chem. Int. Ed. 2019, 58, 13443.
  17. Lin-Lin Zhang, Ji-Wei Zhang, Shao-Hua Xiang*, Zhen Guo*, Bin Tan*. Remote control of axial chirality: Synthesis of spirooxindole–urazoles via desymmetrization of ATAD. Lett. 2018, 20, 6022.
  18. Shao-Hua Xiang, Kim Le Mai Hoang, Jing-Xi He, Yu-Jia Tan, Xue-Wei Liu*. Reversing the Stereoselectivity of a Palladium-catalyzed O-glycosylation through an inner-sphere or outer-sphere pathway. Chem. Int. Ed. 2015, 54, 604.