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  • 李秀秀

    研究助理教授（硕士生导师）
    • 邮箱:lixx7@sustech.edu.cn

    办公室:南方科技大学创园5栋607

    个人主页:

    http://faculty.sustech.edu.cn/lixx7

    • 基本介绍
    • 研究方向
    • 学术成果
    • 其它信息
    教育背景：
    2013.09 − 2018.06: 武汉大学 有机化学    理学博士 （导师：张绪穆教授）

    2009.09 − 2013.06: 武汉大学 化学基地班 理学学士 （导师：张绪穆教授）


    工作经历：
    2023.06 –  至 今  : 南方科技大学    研究助理教授
    2021.11 – 2023.06 : Weizmann Institute of Science  博士后 （导师：Prof. Sergey Semenov）

    2018.07 − 2019.08: 南方科技大学   访问学者 （导师：张绪穆教授）


    荣誉及奖励：
    2021 年获Weizmann Institute of Science “FGS Dean Excellence Fellowships for Postdocs”
    2018 年获“武汉大学学术创新二等奖”
    2017 年获“博士研究生国家奖学金”
    2017 年获“武汉大学榜样珞珈”荣誉称号
    不对称催化：不对称氢化反应；不对称氢甲酰化反应；不对称氢甲酰化串联反应等

    17. Jiahao Wu, Cai You, Xiuxiu Li,*  Xumu Zhang,* Fourfold-selective alkyne-aldehyde reductive coupling in one step.  Sci. Bull. 2025, doi: 10.1016/j.scib.2025.11.056.

    16.  Qishu Chen, Bo Yang, Qiwei Lang, Xiaobing Ding,* Xiuxiu Li,*  Xumu Zhang,* Ir/f-Amphox-Catalyzed Asymmetric Hydrogenation of 1-(Pyridin-2-yl)ketones to Chiral Pyridyl Alcohols. Chin. J. Org. Chem. 2025, 45, 3326-3334.

    15. Longxue Xiang, Cai You,* Xiuxiu Li,* and Xumu Zhang*, Catalytic Intramolecular Reductive Amination Using Secondary Amines: Expanding Access to Chiral Tertiary Amine Heterocycles. Org. Lett. 2025, 27, 6726−6731.

    14. Dequan Zhang, Jianqiang Zheng, Cai You, Liuting Li, Lung Wa Chung, Qifan zhou, Shuailong Li, Tianxiang Ren, Yuhong Yang,* Xumu Zhang* and Xiuxiu Li*, Catalytic Regio- and Enantioselective Hydroformylation of Trisubstituted Alkenes to Construct α-Quaternary Lactams. J. Am. Chem. Soc. 2025, 147, 7886−78961.

    13. Ruiyu Hu, Fan Pan, Cai You, Xiaobing Ding,* Xiuxiu Li,*  Xumu Zhang*，Asymmetric Hydrogenation of β‑Azaaryl α,β-Unsaturated Nitriles: An Access to Ruxolitinib. Org. Lett. 2025, 27, 5260−5263.

    12. Bowen Liu, Chun Zhang,* Xiuxiu Li,* Xumu Zhang. Iridium-catalyzed asymmetric hydrogenation of tetrahydro-γ-carboline: a versatile approach to chiral cis-hexahydro-γ-carboline derivatives compatible with C6-substituted carbolines. Org. Chem. Front., 2025, 12, 2714–2719.

    11. Arpita Paikar,a Xiuxiu Li,a Liat Avram, Barbara S. Smith,d Istvan Süto,  Dezso Horvath,  Elisabeth Rennert, Yuqing Qiu,  Agota Toth,  Suriyanarayanan Vaikuntanathanh, Sergey N. Semenov.Chemical waves in reaction-diffusion networks of small organic molecules. Chem. Sci., 2025, 16, 659–669. (a: contributed equally to this work)

    10. Ruiyu Hu, Fangyuan Wang, Fan Pan, Virginie Ratovelomanana-Vidal, Gen-Qiang Chen,* Xiuxiu Li,*  Xumu Zhang*. Dynamic Kinetic Resolution of β‑Cyano α‑Ketoesters via Asymmetric Transfer Hydrogenation. Org. Lett. 2024, 26, 7457.

    9. Shuailong Li,a Dequan Zhang,a Aiswarya Purushothaman, Hui Lv, Shilpa Shilpa, Raghavan B. Sunoj,* Xiuxiu Li* and Xumu Zhang*, Chemo-, Regio- and Enantioselective Hydroformylation of Trisubstituted Cyclopropenes: Access to Chiral Quaternary Cyclopropanes. Nat. Commun. 2024, 15, 6377. (a: contributed equally to this work)

    8. Xiuxiu Li, Polina Fomitskaya, Viktoryia A. Smaliak, Barbara S. Smith, Ekaterina V. Skorb and Sergey N. Semenov*, Selenium Catalysis Enables Negative Feedback Organic Oscillators. Nat. Commun. 2024, 15, 3316.

    7. Xiuxiu Li,a Cai You,a Jiaxin Yang, Shuailong Li, Dequan Zhang, Hui Lv* and Xumu Zhang*, Asymmetric Hydrocyanation of Alkenes without HCN. Angew. Chem. Int. Ed. 2019, 58, 10928-10931. (Cover Story, Hot Paper, Highlighted by ChemViews, Highlighted by Synfacts, 2019, 15, 1023) (a: contributed equally to this work)

    6. Cai You,a Xiuxiu Li,a Quan Gong, Jialin Wen* and Xumu Zhang*, Nickel-Catalyzed Desymmetric Hydrogenation of Cyclohexadienones: An Efficient Approach to All-Carbon Quaternary Stereocenters. J. Am. Chem. Soc. 2019, 141, 14560-14564. (a: contributed equally to this work)

    5. Cai You,a Xiuxiu Li,a Yuhong, Yang, Yusheng Yang, Xuefeng Tan, Shuailong Li, Biao Wei, Lung Wa Chung,* Hui Lv* and Xumu Zhang*, Silicon-Oriented Regio- and Enantioselective Rhodium-Catalyzed Hydroformylation. Nat. Commun. 2018, 9, 2045. (a: contributed equally to this work)

    4. Xiuxiu Li,a Cai You,a Yusheng Yang, Yuhong Yang, Pan Li, Guoxian Gu, Lung-Wa Chung, Hui Lv* and Xumu Zhang*, Rhodium-Catalyzed Asymmetric Hydrogenation of β-Cyanocinnamic Esters with the Assistance of a Single Hydrogen Bond in a Precise Position. Chem. Sci. 2018, 9, 1919-1924. (a: contributed equally to this work)

    3. Xiuxiu Li, Cai You, Shuailong Li, Hui Lv* and Xumu Zhang*, Nickel-Catalyzed Enantioselective Hydrogenation of β‑(Acylamino)acrylates: Synthesis of Chiral β‑Amino Acid Derivatives. Org. Lett. 2017, 19, 5130-5133.

    2. Xiuxiu Li, a Cai You, a Yusheng Yang, Fangyuan Wang, Shuailong Li, Hui Lv* and Xumu Zhang*, Rhodium-catalyzed Enantioselective Hydrogenation of α-Amino Acrylonitriles: An Efficient Approach to Synthesizing Chiral α-Amino Nitriles. Chem. Commun. 2017, 53, 1313-1316. (a: contributed equally to this work)

    1. Xiuxiu Li,a Cai You,a Hailong Yang, Jinteng Che, Pengyu Chen, Yusheng Yang, Hui Lv* and Xumu Zhang*, Rhodium-Catalyzed Asymmetric Hydrogenation of Tetrasubstituted Cyclic Enamides: Efficient Access to Chiral Cycloalkylamine Derivatives. Adv. Synth. Catal. 2017, 359, 597-602. (Highlighted by Synfacts, 2017, 13, 0292) (a: contributed equally to this work)

李秀秀研究助理教授（硕士生导师）

邮箱:lixx7@sustech.edu.cn

办公室:南方科技大学创园5栋607

个人主页:

http://faculty.sustech.edu.cn/lixx7

  • 基本介绍
  • 研究方向
  • 代表性论文
  • 其它信息
教育背景：
2013.09 − 2018.06: 武汉大学 有机化学    理学博士 （导师：张绪穆教授）

2009.09 − 2013.06: 武汉大学 化学基地班 理学学士 （导师：张绪穆教授）


工作经历：
2023.06 –  至 今  : 南方科技大学    研究助理教授
2021.11 – 2023.06 : Weizmann Institute of Science  博士后 （导师：Prof. Sergey Semenov）

2018.07 − 2019.08: 南方科技大学   访问学者 （导师：张绪穆教授）


荣誉及奖励：
2021 年获Weizmann Institute of Science “FGS Dean Excellence Fellowships for Postdocs”
2018 年获“武汉大学学术创新二等奖”
2017 年获“博士研究生国家奖学金”
2017 年获“武汉大学榜样珞珈”荣誉称号
不对称催化：不对称氢化反应；不对称氢甲酰化反应；不对称氢甲酰化串联反应等

17. Jiahao Wu, Cai You, Xiuxiu Li,*  Xumu Zhang,* Fourfold-selective alkyne-aldehyde reductive coupling in one step.  Sci. Bull. 2025, doi: 10.1016/j.scib.2025.11.056.

16.  Qishu Chen, Bo Yang, Qiwei Lang, Xiaobing Ding,* Xiuxiu Li,*  Xumu Zhang,* Ir/f-Amphox-Catalyzed Asymmetric Hydrogenation of 1-(Pyridin-2-yl)ketones to Chiral Pyridyl Alcohols. Chin. J. Org. Chem. 2025, 45, 3326-3334.

15. Longxue Xiang, Cai You,* Xiuxiu Li,* and Xumu Zhang*, Catalytic Intramolecular Reductive Amination Using Secondary Amines: Expanding Access to Chiral Tertiary Amine Heterocycles. Org. Lett. 2025, 27, 6726−6731.

14. Dequan Zhang, Jianqiang Zheng, Cai You, Liuting Li, Lung Wa Chung, Qifan zhou, Shuailong Li, Tianxiang Ren, Yuhong Yang,* Xumu Zhang* and Xiuxiu Li*, Catalytic Regio- and Enantioselective Hydroformylation of Trisubstituted Alkenes to Construct α-Quaternary Lactams. J. Am. Chem. Soc. 2025, 147, 7886−78961.

13. Ruiyu Hu, Fan Pan, Cai You, Xiaobing Ding,* Xiuxiu Li,*  Xumu Zhang*，Asymmetric Hydrogenation of β‑Azaaryl α,β-Unsaturated Nitriles: An Access to Ruxolitinib. Org. Lett. 2025, 27, 5260−5263.

12. Bowen Liu, Chun Zhang,* Xiuxiu Li,* Xumu Zhang. Iridium-catalyzed asymmetric hydrogenation of tetrahydro-γ-carboline: a versatile approach to chiral cis-hexahydro-γ-carboline derivatives compatible with C6-substituted carbolines. Org. Chem. Front., 2025, 12, 2714–2719.

11. Arpita Paikar,a Xiuxiu Li,a Liat Avram, Barbara S. Smith,d Istvan Süto,  Dezso Horvath,  Elisabeth Rennert, Yuqing Qiu,  Agota Toth,  Suriyanarayanan Vaikuntanathanh, Sergey N. Semenov.Chemical waves in reaction-diffusion networks of small organic molecules. Chem. Sci., 2025, 16, 659–669. (a: contributed equally to this work)

10. Ruiyu Hu, Fangyuan Wang, Fan Pan, Virginie Ratovelomanana-Vidal, Gen-Qiang Chen,* Xiuxiu Li,*  Xumu Zhang*. Dynamic Kinetic Resolution of β‑Cyano α‑Ketoesters via Asymmetric Transfer Hydrogenation. Org. Lett. 2024, 26, 7457.

9. Shuailong Li,a Dequan Zhang,a Aiswarya Purushothaman, Hui Lv, Shilpa Shilpa, Raghavan B. Sunoj,* Xiuxiu Li* and Xumu Zhang*, Chemo-, Regio- and Enantioselective Hydroformylation of Trisubstituted Cyclopropenes: Access to Chiral Quaternary Cyclopropanes. Nat. Commun. 2024, 15, 6377. (a: contributed equally to this work)

8. Xiuxiu Li, Polina Fomitskaya, Viktoryia A. Smaliak, Barbara S. Smith, Ekaterina V. Skorb and Sergey N. Semenov*, Selenium Catalysis Enables Negative Feedback Organic Oscillators. Nat. Commun. 2024, 15, 3316.

7. Xiuxiu Li,a Cai You,a Jiaxin Yang, Shuailong Li, Dequan Zhang, Hui Lv* and Xumu Zhang*, Asymmetric Hydrocyanation of Alkenes without HCN. Angew. Chem. Int. Ed. 2019, 58, 10928-10931. (Cover Story, Hot Paper, Highlighted by ChemViews, Highlighted by Synfacts, 2019, 15, 1023) (a: contributed equally to this work)

6. Cai You,a Xiuxiu Li,a Quan Gong, Jialin Wen* and Xumu Zhang*, Nickel-Catalyzed Desymmetric Hydrogenation of Cyclohexadienones: An Efficient Approach to All-Carbon Quaternary Stereocenters. J. Am. Chem. Soc. 2019, 141, 14560-14564. (a: contributed equally to this work)

5. Cai You,a Xiuxiu Li,a Yuhong, Yang, Yusheng Yang, Xuefeng Tan, Shuailong Li, Biao Wei, Lung Wa Chung,* Hui Lv* and Xumu Zhang*, Silicon-Oriented Regio- and Enantioselective Rhodium-Catalyzed Hydroformylation. Nat. Commun. 2018, 9, 2045. (a: contributed equally to this work)

4. Xiuxiu Li,a Cai You,a Yusheng Yang, Yuhong Yang, Pan Li, Guoxian Gu, Lung-Wa Chung, Hui Lv* and Xumu Zhang*, Rhodium-Catalyzed Asymmetric Hydrogenation of β-Cyanocinnamic Esters with the Assistance of a Single Hydrogen Bond in a Precise Position. Chem. Sci. 2018, 9, 1919-1924. (a: contributed equally to this work)

3. Xiuxiu Li, Cai You, Shuailong Li, Hui Lv* and Xumu Zhang*, Nickel-Catalyzed Enantioselective Hydrogenation of β‑(Acylamino)acrylates: Synthesis of Chiral β‑Amino Acid Derivatives. Org. Lett. 2017, 19, 5130-5133.

2. Xiuxiu Li, a Cai You, a Yusheng Yang, Fangyuan Wang, Shuailong Li, Hui Lv* and Xumu Zhang*, Rhodium-catalyzed Enantioselective Hydrogenation of α-Amino Acrylonitriles: An Efficient Approach to Synthesizing Chiral α-Amino Nitriles. Chem. Commun. 2017, 53, 1313-1316. (a: contributed equally to this work)

1. Xiuxiu Li,a Cai You,a Hailong Yang, Jinteng Che, Pengyu Chen, Yusheng Yang, Hui Lv* and Xumu Zhang*, Rhodium-Catalyzed Asymmetric Hydrogenation of Tetrasubstituted Cyclic Enamides: Efficient Access to Chiral Cycloalkylamine Derivatives. Adv. Synth. Catal. 2017, 359, 597-602. (Highlighted by Synfacts, 2017, 13, 0292) (a: contributed equally to this work)