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  • 顾强帅

    副教授(博士生导师)
  • 邮箱:guqs@sustech.edu.cn
    办公室:南方科技大学慧园6栋407室

    课题组主页:

    https://faculty.sustech.edu.cn/guqs/

    • 基本介绍
    • 研究方向
    • 学术成果
    • 其它信息

    教育背景:

    2008年9月—2013年8月 博士,导师:杨丹教授,香港大学化学系
    2004年9月—2008年6月 学士,中国科学技术大学化学系

    工作经历:

    2024年6月—至今 副教授,南方科技大学深圳格拉布斯研究院
    2024年6月—2024年9月 副研究员,南方科技大学深圳格拉布斯研究院
    2020年11月—2024年6月 研究副教授,南方科技大学前沿与交叉科学研究院
    2017年9月—2020年10月 研究助理教授,南方科技大学前沿与交叉科学研究院
    2016年9月—2017年9月 访问学者/研究助理,南方科技大学化学系刘心元教授课题组 
    2014年7月—2016年9月 博士后,香港大学化学系杨丹教授课题组 
    2012年9月—2014年6月 研究助理,香港大学化学系杨丹教授课题组

    荣誉及奖励:

    2023年度广东省科学技术奖自然科学奖一等奖(第二完成人) 2024年
    中国化学会第三届全国有机自由基化学会议(中国武汉)优秀报告奖 2022年
    深圳市海外高层次人才 “孔雀计划”B类人才 2020年
    香港大学化学系优秀助教奖 2009年、2011年
    安徽省普通高等学校品学兼优毕业生和中国科学技术大学优秀毕业生 2008年
    中国科学技术大学和中国科学院上海有机化学研究所“黄鸣龙奖学金“ 2006年
    中国科学技术大学优秀学生奖学金 2004年、2005年、2007年


    不对称催化、生物活性分子合成、糖化学
    1. Fan, Li-Wen#; Tang, Jun-Bin#; Wang, Li-Lei#; Liu, Ji-Ren#; Li, Zhong-Liang; Zhang, Yu-Shuai; Yuan, Dai-Lei; Qin, Li; Luan, Cheng; Gu, Qiang-Shuai*; Hong, Xin*; Dong, Zhe*; Liu, Xin-Yuan*, Decoupling strategy-enabled radical generality via an asymmetric SH2 path. ChemRxiv 2024, DOI: 10.26434/chemrxiv-2024-3n41t.
    2. Tang, Jun-Bin#; Bian, Jun-Qian#; Zhang, Zhihan#; Cheng, Yong-Feng; Qin, Li; Gu, Qiang-Shuai*; Yu, Peiyuan*; Liu, Xin-Yuan*, Cu(I)-catalysed enantioselective chlorine atom transfer with vinyl radicals. ChemRxiv 2023, DOI: 10.26434/chemrxiv-2023-l3gsz.
    3. Yang, Chang-Jiang*; Liu, Lin; Gu, Qiang-Shuai*; Liu, Xin-Yuan*, Research progress in enantioselective radical desymmetrization reactions. CCS Chem. 2024, DOI: 10.31635/ccschem.024.202303839. (Invited review)
    4. Yu, Zhang-Long#; Cheng, Yong-Feng#; Liu, Ji-Ren; Yang, Wu; Xu, Dan-Tong; Tian, Yu; Bian, Jun-Qian; Li, Zhong-Liang; Fan, Li-Wen; Luan, Cheng; Gao, Ang; Gu, Qiang-Shuai*; Liu, Xin-Yuan*, Cu(I)-catalyzed chemo- and enantioselective desymmetrizing C–O bond coupling of acyl radicals. J. Am. Chem. Soc. 2023, 145, 6535–6545.
    5. Cheng, Yong-Feng#; Yu, Zhang-Long#; Tian, Yu#; Liu, Ji-Ren#; Wen, Han-Tao; Jiang, Na-Chuan; Bian, Jun-Qian; Xu, Guo-Xiong; Xu, Dan-Tong; Li, Zhong-Liang; Gu, Qiang-Shuai*; Hong, Xin*; Liu, Xin-Yuan*, Cu-catalysed enantioselective radical heteroatomic S–O cross-coupling. Nat. Chem. 2023, 15, 395–404.
    6. Yu, Zhanglong; Li, Zhongliang; Yang, Changjiang; Gu, Qiangshuai*; Liu, Xinyuan*, Research progress on copper-catalyzed enantioselective desymmetrization of diols. Acta Chim. Sinica 2023, 81, 955–966. (Invited perspective)
    7. Luan, Cheng#; Yang, Chang-Jiang#; Liu, Lin; Gu, Qiang-Shuai*; Liu, Xin-Yuan*, Transition metal-catalyzed enantioselective C–P coupling reactions for the construction of P-stereogenic centers. Chem Catal. 2022, 2, 2876–2888. (Invited perspective)
    8. Yang, Wu#; Liu, Lin#; Guo, Jiandong#; Wang, Shou-Guo; Zhang, Jia-Yong; Fan, Li-Wen; Tian, Yu; Wang, Li-Lei; Luan, Cheng; Li, Zhong-Liang; He, Chuan; Wang, Xiaotai*; Gu, Qiang-Shuai*; Liu, Xin-Yuan*, Enantioselective hydroxylation of dihydrosilanes to Si-chiral silanols catalyzed by in situ generated copper(II) species. Angew. Chem. Int. Ed. 2022, 61, e202205743.
    9. Wang, Fu-Li#; Yang, Chang-Jiang#; Liu, Ji-Ren#; Yang, Ning-Yuan; Dong, Xiao-Yang; Jiang, Ruo-Qi; Chang, Xiao-Yong; Li, Zhong-Liang; Xu, Guo-Xiong; Yuan, Dai-Lei; Zhang, Yu-Shuai; Gu, Qiang-Shuai*; Hong, Xin*; Liu, Xin-Yuan*, Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes. Nat. Chem. 2022, 14, 949–957.
    10. Tang, Jun-Bin; Bian, Jun-Qian; Zhang, Yu-Shuai; Cheng, Yong-Feng; Wen, Han-Tao; Yu, Zhang-Long; Li, Zhong-Liang; Gu, Qiang-Shuai*; Chen, Guo-Qiang*; Liu, Xin-Yuan*, Copper-catalyzed anti-selective radical 1,2-alkylarylation of terminal alkynes. Org. Lett. 2022, 24, 2536–2540.
    11. Li, Zhuang#; Cheng, Xian-Yan#; Yang, Ning-Yuan; Chen, Ji-Jun; Tang, Wen-Yue; Bian, Jun-Qian; Cheng, Yong-Feng; Li, Zhong-Liang; Gu, Qiang-Shuai*; Liu, Xin-Yuan*, A cobalt-catalyzed enantioconvergent radical negishi C(sp3)–C(sp2) cross-coupling with chiral multidentate N,N,P-ligand. Organometallics 2021, 40, 2215–2219. (Invited paper)
    12. Zhang, Chi; Li, Zhong-Liang; Gu, Qiang-Shuai*; Liu, Xin-Yuan*, Catalytic enantioselective C(sp3)–H functionalization involving radical intermediates. Nat. Commun. 2021, 12, 475. (Invited perspective)
    13. Xia, Hai-Dong#; Li, Zhong-Liang#; Gu, Qiang-Shuai#; Dong, Xiao-Yang#; Fang, Jia-Heng; Du, Xuan-Yi; Wang, Li-Lei; Liu, Xin-Yuan*, Photoinduced copper-catalyzed asymmetric decarboxylative alkynylation with terminal alkynes. Angew. Chem. Int. Ed. 2020, 59, 16926–16932.
    14. Yang, Chang-Jiang#; Zhang, Chi#; Gu, Qiang-Shuai#; Fang, Jia-Heng; Su, Xiao-Long; Ye, Liu; Sun, Yan; Tian, Yu; Li, Zhong-Liang; Liu, Xin-Yuan*, Cu-catalysed intramolecular radical enantioconvergent tertiary β-C(sp3)–H amination of racemic ketones. Nat. Catal. 2020, 3, 539–546.
    15. Yu, Zhang-Long#; Cheng, Yong-Feng#; Jiang, Na-Chuan; Wang, Jian; Fan, Li-Wen; Yuan, Yue; Li, Zhong-Liang; Gu, Qiang-Shuai*; Liu, Xin-Yuan*, Desymmetrization of unactivated bis-alkenes via chiral Brønsted acid-catalysed hydroamination. Chem. Sci. 2020, 11, 5987–5993.
    16. Cheng, Yong-Feng#; Liu, Ji-Ren#; Gu, Qiang-Shuai#; Yu, Zhang-Long#; Wang, Jian; Li, Zhong-Liang; Bian, Jun-Qian; Wen, Han-Tao; Wang, Xiao-Jing; Hong, Xin*; Liu, Xin-Yuan*, Catalytic enantioselective desymmetrizing functionalization of alkyl radicals via Cu(I)/CPA cooperative catalysis. Nat. Catal. 2020, 3, 401–410.
    17. Gu, Qiang-Shuai; Li, Zhong-Liang; Liu, Xin-Yuan*, Copper(I)-catalyzed asymmetric reactions involving radicals. Acc. Chem. Res. 2020, 53, 170–181. (Invited account)
    18. Li, Zhong-Liang#; Fang, Gui-Chun#; Gu, Qiang-Shuai#; Liu, Xin-Yuan*, Recent advances in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes. Chem. Soc. Rev. 2020, 49, 32–48. (Invited review)
    19. Dong, Xiao-Yang#; Zhang, Yu-Feng#; Ma, Can-Liang#; Gu, Qiang-Shuai#; Wang, Fu-Li#; Li, Zhong-Liang; Jiang, Sheng-Peng; Liu, Xin-Yuan*, A general asymmetric copper-catalysed Sonogashira C(sp3)–C(sp) coupling. Nat. Chem. 2019, 11, 1158–1166.
    20. Zeng, Yang#; Liu, Xiao-Dong#; Guo, Xian-Qi; Gu, Qiang-Shuai*; Li, Zhong-Liang*; Chang, Xiao-Yong; Liu, Xin-Yuan*, Cu/chiral phosphoric acid-catalyzed radical-initiated asymmetric aminosilylation of alkene with hydrosilane. Sci. China Chem. 2019, 62, 1529–1536. (Invited paper)
    21. Wang, Na; Gu, Qiang-Shuai*; Cheng, Yong-Feng; Li, Lei; Li, Zhong-Liang; Guo, Zhen*; Liu, Xin-Yuan*, Visible-light promoted preparation of trifluoromethylated tetrahydrofuran and tetrahydropyran. Chin. J. Org. Chem. 2019, 39, 200–206. (Invited paper)
    22. Li, Xue-Fei; Lin, Jin-Shun; Wang, Jian; Li, Zhong-Liang; Gu, Qiang-Shuai*; Liu, Xin-Yuan*, Cu/chiral phosphoric acid-catalyzed asymmetric radical-initiated aminoarylation of alkenes. Acta Chim. Sinica 2018, 76, 878–882. (Invited paper)
    23. Wang, Na#; Gu, Qiang-Shuai#; Li, Zhong-Liang; Li, Zhuang; Guo, Yu-Long; Guo, Zhen; Liu, Xin-Yuan*, Direct photocatalytic synthesis of medium-sized lactams by C–C bond cleavage. Angew. Chem. Int. Ed. 2018, 57, 14225–14229.
    24. Li, Xi-Tao; Lv, Ling; Gu, Qiang-Shuai*; Liu, Xin-Yuan*, Copper-catalyzed radical oxytrifluoromethylation of alkenyl oximes at ambient temperature. Tetrahedron 2018, 74, 6041–6046. (Invited paper)
    25. Wang, Na#; Ye, Liu#; Li, Zhong-Liang; Li, Lei; Li, Zhuang; Zhang, Hong-Xia; Guo, Zhen; Gu, Qiang-Shuai*; Liu, Xin-Yuan*, Hydrofunctionalization of alkenols triggered by the addition of diverse radicals to unactivated alkenes and subsequent remote hydrogen atom translocation. Org. Chem. Front. 2018, 5, 2810–2814. (Invited paper)
    26. Ye, Liu#; Gu, Qiang-Shuai#; Tian, Yu; Meng, Xiang; Chen, Guo-Cong; Liu, Xin-Yuan*, Radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters. Nat. Commun. 2018, 9, 227.
    27. Cheng, Yong-Feng#; Dong, Xiao-Yang#; Gu, Qiang-Shuai#; Yu, Zhang-Long; Liu, Xin-Yuan*, Achiral pyridine ligand-enabled enantioselective radical oxytrifluoromethylation of alkenes with alcohols. Angew. Chem. Int. Ed. 2017, 56, 8883–8886.
    28. Gu, Qiang-Shuai; Yang, Dan*, Enantioselective synthesis of (+)-mitomycin K by a palladium-catalyzed oxidative tandem cyclization. Angew. Chem. Int. Ed. 2017, 56, 5886–5889.
    29. Li, Lei#; Gu, Qiang-Shuai#; Wang, Na; Song, Ping; Li, Zhong-Liang; Li, Xiao-Hua; Wang, Fu-Li; Liu, Xin-Yuan*, 1,2-Difunctionalization-type (hetero)arylation of unactivated alkenes triggered by radical addition/remote (hetero)aryl migration. Chem. Commun. 2017, 53, 4038–4041.
    30. Du, Wei#; Gu, Qiangshuai#; Li, Yang; Lin, Zhenyang; Yang, Dan*, Enantioselective palladium-catalyzed oxidative cascade cyclization of aliphatic alkenyl amides. Org. Lett. 2017, 19, 316–319.
    (#equal contribution; *corresponding author)