邢祥友博士,深圳格拉布斯研究院副研究员,博士生导师,院长助理,深圳市海外高层次人才(孔雀计划C类)。
1. 不对称催化与有机合成
2. 螺旋电子理论
3. 高分子合成(ROMP)
课题组以螺旋电子理论为基础,力求通过手性配体和手性催化剂的精准设计,高效实现相关手性催化过程;详细研究这些转化中手性传递和手性识别的机制和相应的递导规律,阐明官能团电子极化率与手性选择性之间的本质关系,并通过发展的不对称催化体系进行有机小分子的合成研究和高分子合成研究。
Publications in SUSTech:
(12) Shaofeng Li, † Shijie Feng, † Yali Zhou, Chao Liu,Bo Chen,* and Xiangyou Xing*
Development of Highly Enantio- and Z‑Selective Grubbs Catalysts via Controllable C−H Bond Activation.
J. Am. Chem. Soc. 2023, 145(41), 22745-22752. https://doi.org/10.1021/jacs.3c08420
(11) Xingjun Xu †, Yipeng You †, Ming Yu Jin †, Fan-Jie Meng, Chen Xu* and Xiangyou Xing*
Pincer Ru with a single stereogenic identity for highly efficient asymmetric transfer hydrogenation of ketones.
Science China Chemistry 2023, 66(5), 1443–1449. https://doi.org/10.1007/s11426-022-1535-7
(10) Dongxu He, Chen Xu,* and Xiangyou Xing*
Developing Ru-Catalysts for Asymmetric Transfer Hydrogenation of Acyclic Imines.
Org. Lett. 2022, 24(45), 8354–8358. https://doi.org/10.1021/acs.orglett.2c03385
(9) Fumin Chen, Ming Yu Jin, David Zhigang Wang, Chen Xu,* Jianchun Wang,* and Xiangyou Xing*
Simultaneous Access to Two Enantio-enriched Alcohols by a Single Ru-Catalyst: Asymmetric Hydrogen Transfer from Racemic Alcohols to Matching Ketones.
ACS Catal. 2022,12(22),14429–14435. https://doi.org/10.1021/acscatal.2c04657
(8) Ming Yu Jin+, Yali Zhou+, Dengmengfei Xiao+, Yipeng You, Qianqian Zhen, Guanyu Tao, Peiyuan Yu* and Xiangyou Xing*
Simultaneous Kinetic Resolution and Asymmetric Induction within a Borrowing Hydrogen Cascade Mediated by a Single Catalyst.
Angew. Chem. Int. Ed. 2022, 61(3), e202112993. https://onlinelibrary.wiley.com/doi/10.1002/anie.202112993
(7) Yipeng You †, Ming Yu Jin †, Guanyu Tao and Xiangyou Xing *
Highly Efficient Kinetic Resolution of Aryl-Alkenyl Alcohols by Ru-Catalyzed Hydrogen Transfer.
Molecules 2021, 26(24), 7475. https://doi.org/10.3390/molecules26247475
(6) Chengcheng Li, Xiao-Yong Chang, Luqiong Huo, Haibo Tan, Xiangyou Xing*, and Chen Xu*
Hydration of Cyanohydrins by Highly Active Cationic Pt Catalysts: Mechanism and Scope.
ACS Catal. 2021, 11(14), 8716–8726. https://pubs.acs.org/doi/10.1021/acscatal.1c02254
(5) Yali Zhou, Xingjun Xu, Hongwei Sun, Guanyu Tao, Xiao-Yong Chang, Xiangyou Xing*, Bo Chen* and Chen Xu*
Development of highly efficient platinum catalysts for hydroalkoxylation and hydroamination of unactivated alkenes.
Nat. Commun. 2021, 12(1), 1953. https://www.nature.com/articles/s41467-021-22287-w
(4) Dongxu He, Xingjun Xu, Yi Lu, Min-Jie Zhou*, and Xiangyou Xing*
Asymmetric Transfer Hydrogenation of Densely Functionalized Diheteroaryl and Diaryl Ketones by a Ru-Catalyst of Minimal Stereogenicity.
Org. Lett. 2020, 22(21), 8458–8463. https://pubs.acs.org/doi/10.1021/acs.orglett.0c03064
(3) Yupeng Pan, Yipeng You, Dongxu He, Fumin Chen, Xiaoyong Chang, Ming Yu Jin*, and Xiangyou Xing*
Asymmetric Synthesis of gamma-Secondary Amino Alcohols via a Borrowing-Hydrogen Cascade.
Org. Lett. 2020, 22(18), 7278–7283. https://pubs.acs.org/doi/10.1021/acs.orglett.0c02614
(2) Fumin Chen, Dongxu He, Li Chen, Xiaoyong Chang, David Zhigang Wang, Chen Xu*, and Xiangyou Xing*
Chirality-Economy Catalysis: Asymmetric Transfer Hydrogenation of Ketones by Ru-Catalysts of Minimal Stereogenicity.
ACS Catal. 2019, 9(6), 5562–5566. https://pubs.acs.org/doi/10.1021/acscatal.9b01535
(1) Xiangyou Xing, Chen Xu, Bo Chen, Chengcheng Li, Scott C. Virgil*, and Robert H. Grubbs*
Highly Active Platinum Catalysts for Nitrile and Cyanohydrin Hydration: Catalyst Design and Ligand Screening via High-Throughput Techniques.
J. Am. Chem. Soc. 2018, 140(50), 17782–17789. https://pubs.acs.org/doi/10.1021/jacs.8b11667