何川博士,研究员/副教授,PI,国家特聘青年专家,国家优青,广东省珠江引进青年拔尖人才,深圳市海外高层次人才(孔雀计划B类),深圳市南山区领航人才。
教育背景:
2004-2008年,武汉大学,化学与分子科学学院,化学基地班,理学学士。导师:雷爱文。
2008-2013年,武汉大学,化学与分子科学学院,有机化学,理学博士,导师:雷爱文。
2013-2017年,剑桥大学,化学系,博士后/玛丽居里研究员,合作导师:Matthew Gaunt。
工作经历:
2018年-至今,南方科技大学,化学系,副教授/研究员,课题组长,开展独立研究工作。
2013.09-2017.12 —— 博士后/玛丽居里研究员,英国剑桥大学,化学系
荣誉及奖励:
2022年,获得南科大“年度青年教授奖”和“校长青年科研奖”
2021 ——荣获Thieme Chemistry Journals Award 2021
2021 ——荣获国家基金委优秀青年基金
2020 ——入选Chemical Reviews 青年编委(Chemical Reviews Early Career Advisory Board)
2018 —— 深圳市海外高层次人才“孔雀计划”B类
2015 —— 湖北省第十六批优秀博士学位论文
2013 —— 入选中国优秀博士生代表团(全国25人),受邀参加第六十三届德国林岛诺贝尔奖得主大会;Reaxys PhD Prize 入选者
2008 —— 荣获第五届“中国青少年科技创新奖”
1、发展新型的不对称催化反应构建杂原子中心手性
2、基于电催化的新型碳–杂、碳–碳原子成键反应研究
3、新型手性有机材料分子的合成和应用研究
(48) Zu, B.; Guo, Y.; Ren, L-Q.; Li, Y.;* He, C.*
Catalytic Enantioselective Synthesis of Boron-Stereogenic BODIPYs,
Nat. Synth. 2023, accepted.
(47) Gao, J.; He, C.*
Chiral Silanols: Strategies and Tactics for their Synthesis (Invited Concept),
Chem. Eur. J. 2023, e202203475. https://doi.org/10.1002/chem.202203475
(46) Lin, W.; You, L.; Yuan, W.; He, C.*
Cu-Catalyzed Enantioselective Hydrogermylation: Asymmetric Synthesis of Unnatural β-Germyl α-Amino Acids,
ACS Catal. 2022, 12, 14592–14600. https://doi.org/10.1021/acscatal.2c04571
Highlight by "CBG":https://mp.weixin.qq.com/s/ORE-gbITZR-yGy8wHYPLZQ
Highlight by "研之成理":https://mp.weixin.qq.com/s/MLAifA2q4vf-dVO0NXaADg
(45) Ren, L-Q.; Li, N.; Ke, J.;* He, C.*
Recent Advances in Photo- and Electro-Enabled Radical Silylation (Invited Review),
Org. Chem. Front. 2022, 9, 6400−6415. https://doi.org/10.1039/D2QO01387H
(44) Ge, Y.; Huang, X.; Ke, J.; He, C.*
Transition-Metal-Catalyzed Enantioselective C−H Silylation (Invited Review),
Chem. Catal. 2022, 2, 2898−2928. https://doi.org/10.1016/j.checat.2022.07.009
(43) Gao, J.; Mai, P-L.; Ge, Y.; Yuan, W.; Li, Y.;* He, C.*
Copper-Catalyzed Desymmetrization of Prochiral Silanediols to Silicon-Stereogenic Silanols,
ACS Catal. 2022, 12, 8476−8483. https://doi.org/10.1021/acscatal.2c02482
Highlight by "研之成理":https://mp.weixin.qq.com/s/iJ7bx9zdNmy7IWglqpnJEg
(42) Yang, W.; Liu, L.; Guo, J.; Wang, S-G.; Zhang, J-Y.; Fan, L-W.; Tian, Y.; Wang, L-L.; Luan, C.; Li, Z-L.; He, C.; Wang, X.;* Gu, Q-S.;* Liu, X-Y.*
Enantioselective Hydroxylation of Dihydrosilanes to Si-Chiral Silanols Catalyzed by In Situ Generated Copper(II) Species,
Angew. Chem., Int. Ed. 2022, 61, e202205743. https://doi.org/10.1002/anie.202205743
(41) Yuan, W.; Zhu, X.; Xu, Y.; He, C.*
Synthesis of Si-Stereogenic Silanols by Catalytic Asymmetric Hydrolytic Oxidation,
Angew. Chem., Int. Ed. 2022, 61, e202204912. https://doi.org/10.1002/anie.202204912
Highlight by "化学加":https://mp.weixin.qq.com/s/LvRImsz1bJL8BscJRlSB3w
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Highlight by "岳麓化学":https://mp.weixin.qq.com/s/vV4jIgK6jimj0CJpMHdK1A
Highlight by "CBG":https://mp.weixin.qq.com/s/skAUXoZX6UeGV14wR8q1-A
Highlight by "WileyChem":https://mp.weixin.qq.com/s/nrfaSo0vUCTSJxjOjYEI2A
(40) Chen, S.; Zhu, J.; Ke, J.; Li, Y.; He, C.*
Enantioselective Intermolecular C–H Silylation of Heteroarenes for the Synthesis of Acyclic Si-Stereogenic Silanes (Frontispiece Paper),
Angew. Chem., Int. Ed. 2022, 61, e202117820. https://doi.org/10.1002/anie.202117820
Highlight by "X-mol":https://mp.weixin.qq.com/s/OdtM7vZxFKHkV2ASElUL7g
Highlight by "CBG":https://mp.weixin.qq.com/s/cRf3A9UVdbENw9IMaup3wA
Highlight by "WileyChem":https://mp.weixin.qq.com/s/690QzhWSVoF1pqAWonpdmg
Highlight by "化学科讯":https://mp.weixin.qq.com/s/baFC0pw6ZtsOmCTT86PnMQ
(39) Zhu, L.; Guo, Y.; Zu, B.; Ke, J.;* He, C.*
Electrochemical α-Thiolation and Azidation of 1,3-Dicarbonyls,
Chem. Commun. 2022, 58, 2758–2761. https://doi.org/10.1039/D1CC06891A
(38) Yuan, W.; He, C.*
Enantioselective C–H Functionalization toward Silicon-Stereogenic Silanes (Invited Short Review),
Synthesis 2022, 54, 1939–1950. DOI: 10.1055/a-1729-9664
(37) Zu, B.; Guo, Y.; He, C.*
Catalytic Enantioselective Construction of Chiroptical Boron-Stereogenic Compounds,
J. Am. Chem. Soc. 2021, 143, 16302–16310. https://doi.org/10.1021/jacs.1c08482
Highlight by "X-mol":https://mp.weixin.qq.com/s/87t75bqkiO45h9AkHzZfoQ
Highlight by "SYNFACTS": Synfacts 2022, 18(01): 0054. DOI: 10.1055/s-0041-1737205
(36) Liu, W.; Ke, J.; He, C.*
Sulfur Stereogenic Centers in Transition-Metal-Catalyzed Asymmetric C–H Functionalization: Generation and Utilization (Invited Perspective),
Chem. Sci. 2021, 12, 10972−10984. https://doi.org/10.1039/D1SC02614C
(35) You, L.; Yuan, W.; He, C.*
Intermolecular Dehydrogenative C−H/Si−H Cross-Coupling for the Synthesis of Arylbenzyl Bis(silanes),
Eur. J. Org. Chem. 2021, 3079–3082. https://doi.org/10.1002/ejoc.202100474
Special Collection on "Silicon Chemistry in Organic Synthesis"
Highlight by ChemistryViews:https://www.chemistryviews.org/details/ezine/11301891/Access_to_Arylbenzyl_Bissilanes.html
Highlight by "WileyChem":https://mp.weixin.qq.com/s/TgZV0BMr4f3mae5jNEtIzQ
(34) Zhu, J.; He, C.*
Catalytic Enantioselective Synthesis of Silicon-Stereogenic Alkoxysilanes and Siloxanes (Invited Synpacts),
Synlett 2021, 32, 1575–1580. DOI: 10.1055/a-1503-7976
Highlight by "CBG":https://mp.weixin.qq.com/s/tUW-qSNypqDzwHnWIT-4FQ
(33) Guo, Y.; Liu, M.-M.; Zhu, X.; Zhu, L.; He, C.*
Catalytic Asymmetric Synthesis of Silicon-Stereogenic Dihydrodibenzosilines: Silicon-Central to Axial Chirality Relay,
Angew. Chem., Int. Ed. 2021, 60, 13887−13891. https://doi.org/10.1002/anie.202103748
Highlight by "WileyChem":https://mp.weixin.qq.com/s/r2GiWG-Jmtu_NnAAPldFiQ
Highlight by "X-mol":https://mp.weixin.qq.com/s/oxTHO3MXgXnD1cYLcJtmwA
(32) Zhu, J.; Chen, S.; He, C.*
Catalytic Enantioselective Dehydrogenative Si–O Coupling to Access Chiroptical Silicon-Stereogenic Siloxanes and Alkoxysilanes,
J. Am. Chem. Soc. 2021, 143, 5301−5307. https://doi.org/10.1021/jacs.1c01106
Highlight by "X-mol":https://mp.weixin.qq.com/s/bHwowbqOCBpc9U44gVa-sg
Highlight by "化学加":https://mp.weixin.qq.com/s/qQsv78HAQa8FQg9cme17Ww
Highlight by "Organic Chemistry Portal":https://www.organic-chemistry.org/abstracts/lit7/881.shtm
(31) Ke, J.; Liu, W.; Zhu, X.; Tan, X.; He, C.*
Electrochemical Radical Silyl-Oxygenation of Activated Alkenes,
Angew. Chem., Int. Ed. 2021, 60, 8744−8749. https://doi.org/10.1002/anie.202016620
Highlight by "WileyChem":https://mp.weixin.qq.com/s/4IoPnNv_Wa8XdkwUPR9OSw
Highlight by "X-mol":https://mp.weixin.qq.com/s/H3NQWDg-2BChz3udHliDHw
Highlight by "IKA":https://mp.weixin.qq.com/s/Q02ByIN-ay-qP2au8YpWhw
(30) Zu, B.; Guo, Y.; Ke, J.; He, C.*
Transient and Native Directing Group Enabled Enantioselective C–H Functionalization (Invited Short Review),
Synthesis 2021, 53, 2029–2042. DOI: 10.1055/a-1372-6627
(29) Yuan, W.; You, L.; Lin, W.; Ke, J.; Li, Y.; He, C.*
Asymmetric Synthesis of Silicon-Stereogenic Monohydrosilanes by Dehydrogenative C–H Silylation,
Org. Lett. 2021, 23, 1367−1372. http://dx.doi.org/10.1021/acs.orglett.1c00029
Highlight by "CBG":https://mp.weixin.qq.com/s/mQzFs4aWuwdhOZJUw6nJMQ
(28) Chen, S.; Mu, D.; Mai, P-L.; Ke, J.; Li, Y.; He, C.*
Enantioselective Construction of Six- and Seven-Membered Triorgano-Substituted Silicon-Stereogenic Heterocycles,
Nat. Commun. 2021, 12, 1249. https://doi.org/10.1038/s41467-021-21489-6
Highlight by "X-mol":https://mp.weixin.qq.com/s/qSpRCvKSSHHHPVduuSxWYQ
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(27) Ke, J.; Zu, B.; Guo, Y.; Li, Y.; He, C.*
Hexafluoroisopropanol-Enabled Copper-Catalyzed Asymmetric Halogenation of Cyclic Diaryliodoniums for the Synthesis of Axially Chiral 2,2'-Dihalobiaryls,
Org. Lett. 2021, 23, 329−333. http://dx.doi.org/10.1021/acs.orglett.0c03833
共发表学术论文和专著48篇,论文引用3000+次(Google Scholar);国家发明专利14项。
2018年独立工作以来,以南科大为第一单位,发表通讯作者论文27篇,包括Nat. Synth. 1篇,Chem 1篇,J. Am. Chem. Soc. 3篇,Angew. Chem. Int. Ed. 5篇,Nat. Commun. 1篇,ACS Catal. 3篇,Chem. Sci. 2篇等。
创新成果简介如下:
1、围绕发展新型不对称催化反应高效构建杂原子中心手性(硅中心手性,硫中心手性等),开展了一系列的研究工作,积累了丰富的结果。
2、围绕发展有机电催化新反应,以绿色化学和可持续发展的理念为指导,以提高反应效率、选择性、原子经济性为目标,设计发展电催化的新成键模式和合成方法,快速有效地构建有机分子和目标产物。
3、围绕发展的反应为模型,运用在线红外、同步辐射等新技术对其进行详细系统的反应动力学和机理研究,对现代偶联反应中的一些物理有机化学基本问题进行了探索。